Insulin can boost your immune system, here’s how

(THIS ARTICLE IS COURTESY OF THE HINDUSTAN TIMES OF INDIA)

 

Insulin can boost your immune system, here’s how

Insulin, a hormone produced by beta cells of the pancreatic islets, can boost your immune health, says a new study.

HEALTH Updated: Aug 31, 2018 11:35 IST

Asian News International
Insulin,Health,Immune system
A lot of research has been done on the role of insulin in organs such as the liver, muscle and in fat to understand the regulation of glucose or blood sugar.(Shutterstock)

Insulin, a peptide hormone produced by beta cells of the pancreatic islets, boosts immune health, according to a new study. Toronto General Hospital Research Institute (TGHRI) scientists have identified a specific insulin signalling pathway that, when activated, revs up the response of T cells in the immune system to divide rapidly and secrete cytokines, chemical messenger proteins that activate the rest of the immune system.

A fast and effective immune response protects us against disease and life-threatening infections by destroying infected cells or microbes, while a wrong or inefficient one can cause immune system disorders or diseases to develop. “We have identified one of metabolism’s most popular hormones, specifically the insulin signalling pathway, as a novel ‘co-stimulatory’ driver of immune system function,” said Assistant Professor Dr Dan Winer.

Although much work has been done on the role of insulin in organs such as the liver, muscle and in fat to understand the regulation of glucose or blood sugar and how the body metabolises or turns it into energy, little is known about how insulin impacts the immune system.

The goal of this research was to study how insulin regulates T cell function and what causes T cells to stop responding to insulin, Dr Tsai says, adding that T cells were chosen because they play a pivotal role in self-defense against infections. Using genetically engineered mice, the research team designed mice with T cells that did not have an insulin receptor on them, mimicking insulin resistance. They then observed what happened to the T cells in the mice under different stressors, such as the H1N1 flu virus.

Without the added boost or kickstart provided by the insulin receptor to help “re-energize” the T cells to mount an effective immune response, the T cells failed to destroy viruses such as H1N1 influenza. First author Dr Sue Tsai said, “In the future, we could harness this insulin signalling pathway to either boost the immune response to create vaccines, for example, or dampen it to heal inflammatory illnesses such as arthritis, ulcerative colitis and Crohn’s disease.” The full findings are present in the journal Cell Metabolism.

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First Published: Aug 31, 2018 11:34 IST

Heroin: What The Hell Are We Doing To Yourselves Folks?

Heroin: What The Hell Are We Doing To Yourselves Folks?

 

For those of you who do not know me from this blog I will tell you up front that what I am going to say if from my life’s experiences now being over 60 years old. I have never stuck a needle in myself for the purpose of getting some kind of a high, or even to decrease my own pain. I have had medical people do their thing quite a few times where I felt like a wore out pin-cushion before I got out of their care, but I have never stuck myself. I really hope that I do not end up needing Insulin shots someday. But, I have had quite a few folks whom I quickly found out where poking needles in themselves when they would get home from work or on the weekends for the purpose of getting a high was part of their normal day. As I set and watched quite a few people poking themselves or having their friends do it for them and putting them in very painful places, I had to wonder how, how and why they are where they are at this point in their lives? We hear on the news quite often now how Heroin is a major epidemic in many places in America today. I did not know until about a year ago that heroin is actually a very cheep costing drug, I had always though it would be a very expensive drug until I found out it is made from Morphine.

 

For those of you who have decided to first put a needle in yourself, I’m not talking about the first time you let someone else do it to/for you, I’m asking about the first time you yourself stuck a needle in yourself for the purpose of getting high, was it that? Was it in an attempt to get out of some type of pain, mental or physical? If there are ten million people in America alone that put that first drug, that first needle, in our-self, by our-self, are there ten million different stories? Stories of loss, of pain, of stupidity? In the ‘wired world’ about everyone has to have heard a lot of really bad things about this drug getting a power over you that you can no longer control so why? Why did you do that to yourself? All of the people who I knew way back then are gone now, old memories, I don’t know of any that made it anywhere near fifty. I have seen a few cases where people gradually got off of the drugs they were shooting up by turning more and more to the use of marijuana to calm themselves and start to see the world clearer and got themselves off of their own personal demon. I have learned and seen that marijuana is really a ‘step down drug’ that does help some folks, this ‘medication’ being illegal is insane and inhumane. There is another absolute fact and that is where Marijuana is a legal drug, pain pill use goes way down. Heroin or Morphine pills or how about the God-given medicine instead of the hundreds of billions of dollars spent on these pills, and then there is this Demon called Heroin that is killing so many people. The ‘War On Drugs’ got this part backwards folks. Drugs like Heroin are a disease on the human race as are these millions of ‘Pill Heads’ that the system is helping fan the flames of.

Heroin: What The Hell Are We Doing To Yourselves Folks?

Heroin: What The Hell Are We Doing To Yourselves Folks?

 

For those of you who do not know me from this blog I will tell you up front that what I am going to say if from my life’s experiences now being over 60 years old. I have never stuck a needle in myself for the purpose of getting some kind of a high, or even to decrease my own pain. I have had medical people do their thing quite a few times where I felt like a wore out pin-cushion before I got out of their care, but I have never stuck myself. I really hope that I do not end up needing Insulin shots someday. But, I have had quite a few folks whom I quickly found out where poking needles in themselves when they would get home from work or on the weekends for the purpose of getting a high was part of their normal day. As I set and watched quite a few people poking themselves or having their friends do it for them and putting them in very painful places, I had to wonder how, how and why they are where they are at this point in their lives? We hear on the news quite often now how Heroin is a major epidemic in many places in America today. I did not know until about a year ago that heroin is actually a very cheep costing drug, I had always though it would be a very expensive drug until I found out it is made from Morphine.

 

For those of you who have decided to first put a needle in yourself, I’m not talking about the first time you let someone else do it to/for you, I’m asking about the first time you yourself stuck a needle in yourself for the purpose of getting high, was it that? Was it in an attempt to get out of some type of pain, mental or physical? If there are ten million people in America alone that put that first drug, that first needle, in our-self, by our-self, are there ten million different stories? Stories of loss, of pain, of stupidity? In the ‘wired world’ about everyone has to have heard a lot of really bad things about this drug getting a power over you that you can no longer control so why? Why did you do that to yourself? All of the people who I knew way back then are gone now, old memories, I don’t know of any that made it anywhere near fifty. I have seen a few cases where people gradually got off of the drugs they were shooting up by turning more and more to the use of marijuana to calm themselves and start to see the world clearer and got themselves off of their own personal demon. I have learned and seen that marijuana is really a ‘step down drug’ that does help some folks, this ‘medication’ being illegal is insane and inhumane. There is another absolute fact and that is where Marijuana is a legal drug, pain pill use goes way down. Heroin or Morphine pills or how about the God-given medicine instead of the hundreds of billions of dollars spent on these pills, and then there is this Demon called Heroin that is killing so many people. The ‘War On Drugs’ got this part backwards folks. Drugs like Heroin are a disease on the human race as are these millions of ‘Pill Heads’ that the system is helping fan the flames of.