Justice Ruth Bader Ginsburg Treated Again For Cancer

(THIS ARTICLE IS COURTESY OF NPR NEWS)

 

Justice Ruth Bader Ginsburg Treated Again For Cancer

Supreme Court Justice Ruth Bader Ginsburg speaks with NPR in July.

Shuran Huang/NPR

Updated at 2:37 p.m. ET

Justice Ruth Bader Ginsburg has just completed three weeks of radiation treatment at Memorial Sloan Kettering Cancer Center in New York, the U.S. Supreme Court disclosed Friday.

The radiation therapy, conducted on an outpatient basis, began Aug. 5, shortly after a localized cancerous tumor was discovered on Ginsburg’s pancreas. The treatment included the insertion of a stent in Ginsburg’s bile duct, according to a statement issued by the court.

Doctors at Sloan Kettering said further tests showed no evidence of disease elsewhere in the body. The treatment comes just months after Ginsburg was operated on for lung cancer last December. The 86-year-old justice has been treated for cancer in various forms over the past 20 years.

“Justice Ruth Bader Ginsburg today completed a three-week course of stereotactic ablative radiation therapy at Memorial Sloan Kettering Cancer Center in New York City,” a statement from the Supreme Court read. “The focused radiation treatment began on August 5 and was administered on an outpatient basis to treat a tumor on her pancreas. The abnormality was first detected after a routine blood test in early July, and a biopsy performed on July 31 at Sloan Kettering confirmed a localized malignant tumor.

“As part of her treatment, a bile duct stent was placed. The Justice tolerated treatment well. She cancelled her annual summer visit to Santa Fe, but has otherwise maintained an active schedule. The tumor was treated definitively and there is no evidence of disease elsewhere in the body. Justice Ginsburg will continue to have periodic blood tests and scans. No further treatment is needed at this time.”

Shortly before her new round of treatment, Ginsburg sat for an interview with NPR, and her resilience was on full display.

“There was a senator, I think it was after my pancreatic cancer, who announced with great glee that I was going to be dead within six months,” Ginsburg said. “That senator, whose name I have forgotten, is now himself dead, and I,” she added with a smile, “am very much alive.”

During Ginsburg’s three weeks of treatment in New York, she kept up a busy schedule in New York, often going out in the evening to the movies, the opera and the theater.

At the National Yiddish Theatre Folksbiene, where Fiddler on the Roof is playing, word spread during intermission that Ginsburg was there, and the audience stood for several minutes applauding the diminutive justice.

Also in the audience that night was Kate McKinnon, whose frequent portrayal of Ginsburg on NBC’s Saturday Night Live has become a marquee event on the show. Soon, the justice and her imitator were caught in photos clasping hands for the first time.

The justice also continued to work during her time in New York, according to court sources, and she has been spotted frequently window shopping, even going in to try on shoes and other items that have interested her.

Ginsburg has 11 public events planned for September and has not canceled any of them to date.

The Supreme Court is set to open a new term on the first Monday in October, and the justices routinely return to work in September.

President Trump has already named two conservative justices to the court, thus ensuring a five-justice conservative majority in most controversial cases.

Were Ginsburg to leave the court prior to the 2020 election or even the inauguration, Senate Republican leader Mitch McConnell has made clear the GOP would move immediately to fill the vacancy. That would ensure a 6-to-3 conservative majority on the court, all but guaranteeing a conservative grip on the court for decades to come.

Israel: Nano-vaccine against melanoma developed by Tel Aviv University researchers

(THIS ARTICLE IS COURTESY OF THE TIMES OF ISRAEL)

 

Nano-vaccine against melanoma developed by Tel Aviv University researchers

New approach to deadly skin cancer has been effective in preventing and treating primary tumors in mice, study says

Illustrative image of a doctor using a dermatoscope for a skin examination for melanoma (AndreyPopov, iStock by Getty Images)

Illustrative image of a doctor using a dermatoscope for a skin examination for melanoma (AndreyPopov, iStock by Getty Images)

Researchers at Tel Aviv University say they may have developed a new way to treat and prevent melanoma, through the use of a “nano-vaccine.”

The new approach to fighting the most aggressive type of skin cancer has so far been effective in mice in preventing the development of melanoma and in treating primary tumors and metastases that result from melanoma, the researchers said in a study.

“Our research opens the door to a completely new approach — the vaccine approach — for effective treatment of melanoma, even in the most advanced stages of the disease,” said a statement by Prof. Satchi-Fainaro, chair of the Department of Physiology and Pharmacology and head of the Laboratory for Cancer Research and Nano-medicine at TAU’s Sackler Faculty of Medicine, who led the study.

The focus of the research, published on Monday in Nature Nanotechnology, is a nano-particle that serves as the basis for the new vaccine.

A nano-vaccine developed by researchers at Tel Aviv University enhances the sensitivity of melanoma to immunotherapy to destroy cancer cells. Illustration by Maayan Harel.

Melanoma develops in the skin cells that produce melanin or skin pigment. The cancer accounts for only about 1% of skin tumors, but is behind a large majority of skin cancer deaths, according to the American Cancer Society. Some 7,230 people in the US are expected to die of melanoma in 2019, according to the American Cancer Society.

“The war against cancer in general, and melanoma in particular, has advanced over the years through a variety of treatment modalities, such as surgery, chemotherapy, radiation therapy and immunotherapy; but the vaccine approach, which has proven so effective against various viral diseases, has not materialized yet against cancer,” said Satchi-Fainaro. “In our study, we have shown that it is possible to produce an effective nano-vaccine against melanoma and to sensitize the immune system to immunotherapies.”

The researchers used tiny particles, about 170 nano-meters in size, made up of  biodegradable polymers. Within each particle, they “packed” two peptides — short chains of amino acids, which are found in melanoma cells. They then injected the nano-particles (or “nano-vaccines”) into mice that had melanoma.

“The nano-particles acted just like known vaccines for viral-borne diseases,” Satchi-Fainaro said. “They stimulated the immune system of the mice, and the immune cells learned to identify and attack cells containing the two peptides — that is, the melanoma cells. This meant that, from now on, the immune system of the immunized mice will attack melanoma cells if and when they appear in the body.”

Tel Aviv University researchers have developed nano-vaccine to fight melanoma in mice. Left to right: Prof. Helena Florindo, Dr João Conniot, Prof. Ronit Satchi-Fainaro, Dr Anna Scomparin. (Galia Tiram).

The researchers then examined the effectiveness of the vaccine under three conditions.

In the first scenario, the vaccine was injected into healthy mice, followed by an injection of melanoma cells. “The result was that the mice did not get sick, meaning that the vaccine prevented the disease,” Satchi-Fainaro said. This means the vaccine proved to have a preventative effect, she explained.

Second, the nano-particle vaccine was used to treat a primary melanoma tumors in mice, together with immunotherapy treatments that are already approved for use or still under development. The combination of the vaccine with the treatment “significantly delayed the progression of the disease and greatly extended the lives of all treated mice,” the statement said.

In the last scenario, the researchers tested their approach on tissues taken from human patients in which the melanoma cancer cells had spread to the brain. They found that in the human brain, where there is metastases, the two same peptides exist. This suggested that just as these two peptides can trigger an immune reaction in mice when used as a nano-vaccine, they are likely to trigger a similar reaction in the brain, indicating that the vaccine could be used to treat brain metastases in humans as well, Satchi-Fainaro said in a phone interview.

A nano-vaccine developed by researchers at Tel Aviv University activates the immune system to attack melanoma (Illustration by Galia Tiram).

The next step for the researchers, she  said in the phone interview, is to “show that we can control the growth” of the metastasized cells in order to “prolong overall survival.”

The researchers believe that their “nano-vaccine” approach could be expanded beyond melanoma.

“We believe that our platform may also be suitable for other types of cancer and that our work is a solid foundation for the development of other cancer nano-vaccines,” Satchi-Fainero said.

The researchers are now setting up a company to take the development of their nano-vaccine further. It may take at least five to 10 years before a product could reach the market, if all the clinical trials go well, she said in the interview.

The team of researchers included Prof. Helena Florindo of the University of Lisbon, while on sabbatical at the TAU, and Dr. Anna Scomparin and postdoctoral fellow Dr. João Conniot, both of the TAU.

The project was funded by EuroNanoMed-II, the Israeli Health Ministry, the Portuguese Foundation for Science and Technology (FCT), the Israel Science Foundation (ISF), the European Research Council (ERC) Consolidator and Advanced Awards, the Saban Family Foundation – Melanoma Research Alliance (MRA) Team Science Award, and the Israel Cancer Research Fund (ICRF).

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What do the Zodiac signs really mean?

(THIS ARTICLE IS COURTESY OF TRIVIA GENIUS)

 

General

What do the Zodiac signs really mean?

In astrology, the 12 Zodiac signs are a loose guide to personality traits, which are a reflection of the behavior, attitude, passion, strengths, and weaknesses of people under each classification. They can be used for self-improvement, growth, entertainment, and fun!

Individuals are associated with a symbol—or a sign—depending on the date and month on which they were born. The 12 signs are Aries, Taurus, Gemini, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, and Pisces.

These signs fall into elemental classifications of water (Cancer, Scorpio, Pisces); air (Gemini, Libra, Aquarius); fire (Aries, Leo, Sagittarius); and earth (Taurus, Virgo, Capricorn). These four elements have perceived underpinnings in their interaction with the 12 Zodiac signs.

Aries

Credit: BlackJack3D / iStockPhoto

People who fall under this horoscope are those born between March 20 and April 20, and the representative symbol is the ram. This Zodiac sign represents people who are bold, courageous, ambitious, inquisitive, independent, natural leaders, and individuals who have a deep respect for justice. The negative characteristics of this group include aggression, selfishness, inconsistency, bad temperament, and pushy characteristics.

Taurus

Credit: BlackJack3D / iStockPhoto

Taureans are born between April 20 and May 20, under the bull. The characteristics are dedication, trustworthiness, and dependency compared to the negative traits like resistance to change and stubbornness. The bull signifies persistence and high energy, which propagates an endurance that extends beyond high patience levels.

Gemini

Credit: BlackJack3D / iStockPhoto

This zodiac class depicts twins as the symbol and consists of people born between May 21 and June 20. These individuals are agile, open to change, intelligent, have excellent communication skills, are insightful, and possess a readiness to make conversation. Within this category, their behaviors are inconsistent, they like to over-stress or amplify situations and information, and they are deceptive, scheming, dramatic, and extremely talkative.

Cancer

Credit: BlackJack3D / iStockPhoto

Birthdays of people under Cancer run from June 21 to July 20, and the symbol is the crab. The traits of members include compassion, healing, cultivating, reassuring, understanding, and incredibly loving. However, the same people display clingy behavior, passive aggression, moodiness, and indirect expressions, which hinder effective interaction.

Leo

Credit: BlackJack3D / iStockPhoto

The representation sign is the lion, and the birth dates run from July 21 to August 20. Their association with the sun means that Leos introduce warmth to an interaction or bring a relationship to life. Hence, this group values relationships, and their charisma can charm many people into becoming their friends. Leos are also fearless, protective, fun, exhibit leadership, and are very generous, which parallels their inclination to dictatorship, stubbornness, and controlling and bragging behavior.

Virgo

Credit: BlackJack3D / iStockPhoto

The virgin is the zodiac symbol that describes people born between August 21 and September 20. People in this category come off as organized, investigative, rational, meek, modest, and responsible. They have an excellent memory and research skills, which makes it possible to be rational and analytical. This makes them an excellent addition to a discussion group. However, they can prove to be annoying due to their obsessive behavior, desire to make everything perfect, criticalness, and an extreme keenness to detail.

Libra

Credit: BlackJack3D / iStockPhoto

Represented by the scales, Libras have their birthdays between September 20 and October 20. Members of this group have dignity, are easygoing, subtle, and charming despite their indecisive traits and hypocritical and gullible attitudes.

Scorpio

Credit: BlackJack3D / iStockPhoto

Depicted by the scorpion, this zodiac sign describes people born between October 21 and November 20. Beyond the passionate, sensitive, expressive, and sacrificial characteristics, this group also displays envious, distrustful, malicious, and possessive behavior.

Sagittarius

Credit: BlackJack3D / iStockPhoto

The centaur (or an archer) is the representative symbol for Sagittarius, for people born between November 21 and December 21. This is a hopeful group due to their open-mindedness, and are bubbly, lucky, possess high moral standards, and are versatile. Negative aspects include sluggishness and being fidgety, irresponsible, and greedy.

Capricorn

Credit: BlackJack3D / iStockPhoto

The symbol for Capricorn is the goat. This group is talented and values stability, strategy, tolerance, meticulousness, and responsibility irrespective of their negativity, rigidity, ruthlessness, and melancholic and cynical traits. Capricorns are born between December 21 and January 20.

Aquarius

Credit: BlackJack3D / iStockPhoto

The Aquarius sign is also known as the Water Bearer, based on the symbol, and is comprised of individuals born between January 21 and February 20. The group reflects inherent characteristics such as intellectual or smart, generous, friendly, creative, and humane. The negative traits associated with this sign are irresponsible, emotionally distant, absent-minded, and impersonal.

Pisces

Credit: BlackJack3D / iStockPhoto

This Zodiac sign is the fish and signifies the temperament and attitudes of people born between February 21 and March 20. Pisces is romantic, thoughtful, sensitive, inventive, and empathetic, which complements the problematic elements of being unrealistic, docile, self-pitying, and needy.

Israeli researchers find ‘potential hope’ for some pancreatic cancer patients

(THIS ARTICLE IS COURTESY OF THE TIMES OF ISRAEL)

 

Israeli researchers find ‘potential hope’ for some pancreatic cancer patients

New drug stalls progression of disease for patients who have the BRCA genetic mutations, study by Sheba Medical Center with AstraZeneca and Merck shows

An illustrative image of a cancer patient and perfusion drip. (CIPhotos, iStock by Getty Images)

An illustrative image of a cancer patient and perfusion drip. (CIPhotos, iStock by Getty Images)

Researchers at Israel’s Sheba Medical Center at Tel Hashomer said Sunday that a targeted cancer therapy drug they developed together with pharma giants AstraZeneca and Merck & Co. Inc. offers “potential hope” for patients with a specific kind of pancreatic cancer, as it delays the progression of the disease.

Dr. Talia Golan, the head of the Sheba Medical Center Pancreatic Cancer Center, has been conducting research and clinical trials with AstraZeneca and MSD, as Merck is called outside the US, to evaluate the safety and test the efficacy of a new drug treatment regimen based on Lynparza, or olaprib, tablets.

The tablets are a pharmacological inhibitor of the enzyme poly (ADP-ribose) polymerase, or PARP. PARP inhibitors are a group of drugs that inhibit the enzyme. They were developed for a number of indications, but most importantly for the treatment of cancer, as several forms of cancer are more dependent for their development on the enzyme than regular cells are. This makes PARP an attractive target for cancer therapy.

Those who received the medication in the study on average went 7.4 months before their disease began to worsen, known as “progression free survival” rates, compared to 3.8 months in the group that took the placebo, the researchers said.

The study, called POLO, was held with 154 patients with metastatic pancreatic cancer who carried the BRC -1 and BRCA-2 genetic mutations. Patients with these mutations “make up a small subgroup of those with metastatic pancreatic cancer,” the researchers said in their study. Golan said in an interview that this subgroup accounts for six to seven percent of the metastatic pancreatic cancer patients.

The results of the Phase III randomized, double-blind study with a placebo control group will be published in July in the New England Journal of Medicine, the partners said.

“The POLO trial using the medicine Lynparza offers potential hope for those who suffer from metastatic pancreatic cancer and have a BRCA mutation,” Golan said in the statement. “This treatment also exemplifies the advent of ‘precision medicine’ based on a specific genetic biomarker, BRCA 1 & 2.”

In the study, patients were randomly assigned to get the tablets, at a dose of 300 milligram twice daily, or a placebo.

However, though the drug was seen to slow the disease’s progression, an interim analysis showed “no difference” in overall survival between those who took the drug and the placebo group — a median of 18.9 months versus 18.1 months, the study said.

Pancreatic cancer is the 12th most common cancer worldwide, with 458,918 new cases in 2018 alone. It is the fourth leading cause of cancer death, and accounts for 7% of all cancer deaths, according to Cancer.Net. The five-year survival rate for people with pancreatic cancer is 9%. The cancer is often difficult to diagnose, as there are no specific cost-effective ways to screen for the illness, meaning that it is often found at later stages, when it has spread. For the 52% of people who are diagnosed after the cancer has spread, the 5-year survival rate is 3%, Cancer.Net says.

“When we saw the results were positive it was an exceptional, phenomenal moment,” said Golan in an interview. “For the field it is a huge thing.”

She added that this is the first Phase 3 biomarker study that is positive in pancreatic cancer and the drug “provides tremendous hope for patients” with the advanced stage of the cancer.  “This drug has shown efficacy and a tremendous really phenomenal response in this patient population,” she said.

BRCA1 and BRCA2 are human genes that produce proteins responsible for repairing damaged DNA and play an important role in maintaining the genetic stability of cells. When either of these genes is mutated, or altered, such that its protein product either is not made or does not function correctly, DNA damage may not be repaired properly, and cells become unstable. As a result, cells are more likely to develop additional genetic alterations that can lead to cancer. A significant number of Ashkenazi Jews (those of European origin) around the world are carriers of the BRCA 1 & 2 genes.

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JUNE 4, 2019
CURRENT TOP STORIES

Mother of Nechama Rivlin’s lung donor: ‘Another part of you has gone’

Sari Halabli, mother of 19-year-old Yair who died in March drowning accident, eulogizes president‘s ‘modest’ wife, says she will ‘rest in peace, together with my enchanting son’

Nechama Rivlin (R), wife of President Reuven Rivlin, on June 16, 2016. (Moshe Shai/FLASH90)
Yair Yehezkel Halabli (L), who donated his lung to Rivlin. (Twitter)

Nechama Rivlin (R), wife of President Reuven Rivlin, on June 16, 2016. (Moshe Shai/FLASH90) Yair Yehezkel Halabli (L), who donated his lung to Rivlin. (Twitter)

The mother of the young man whose lung was transplanted into Nechama Rivlin said Tuesday she grieves the passing of President Reuven Rivlin’s wife.

Sari Halabli, the mother of 19-year-old Yair Halabli, who died in March after drowning in a diving accident in Eilat, said Rivlin’s death at the age of 73 meant another part of her son had died.

Rivlin was “a modest woman, just like Yair,” Halabli told the Ynet news site.

“Rest in peace, together with my enchanting son,” she said in a message to Rivlin, before addressing her late son: “Another part of you has gone, and of my heart.”

Memorial candles are lit next to a picture of Nechama Rivlin, the late wife of President Reuven Rivlin, outside the President’s Residence in Jerusalem on June 4, 2019. (Yonatan Sindel/Flash90)

Halabli’s family donated several of his organs after his death. Rivlin received his lung on March 11 after a long time on a waiting list as she suffered from pulmonary fibrosis, a condition in which scar tissue accumulates in the lungs and makes it difficult to breathe. She died earlier Tuesday from complications linked to the transplant.

Her funeral will be held Wednesday at 6 p.m. at the Mount Herzl national cemetery in Jerusalem. Prior to the ceremony, her coffin will be placed at the Jerusalem Theater, where the public can go to pay its respects.

On Thursday and Friday, the president and his family will receive condolence visits at his official residence in Jerusalem as part of the traditional Shiva mourning period.

“I’m happy Nechama is no longer suffering. She really deserves the love she is getting now and the recognition of her service and work,” Channel 12 news quoted Rivlin telling friends following his wife’s death.

Rivlin died on the eve of her 74th birthday at Beilinson Hospital in Petah Tikva, where she was being treated after relapsing following the lung transplant.

President Reuven Rivlin and his wife, Nechama Rivlin. (GPO)

Soft-spoken and mild-mannered, Rivlin was eulogized by Israeli politiciansfrom across the political spectrum. She was also mourned by foreign diplomats stationed in Israel, as well as US President Donald Trump’s envoy for Middle East peace.

Trump, French President Emmanuel Macron and German President Frank Walter Steinmeier all called Rivlin’s office to express their condolences, according to Channel 12, which reported the president only spoke by phone with a few close friends of his and his late wife’s.

Nechama Rivlin was born in 1945 in Moshav Herut in the Sharon region. She married Reuven Rivlin in 1971, and worked for many years at the Hebrew University of Jerusalem, until her retirement in 2007, at which point her lung condition was discovered.

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How the humble cabbage can stop cancers

(THIS ARTICLE IS COURTESY OF THE BBC)

 

How the humble cabbage can stop cancers

CabbageImage copyright GETTY IMAGES

Scientists say they have discovered why some vegetables – including cabbage, broccoli and kale – can reduce the risk of bowel cancers.

That cruciferous veg is good for the gut has never been in doubt but a detailed explanation has been elusive.

The team at the Francis Crick Institute found anti-cancer chemicals were produced as the vegetables were digested.

Cancer Research UK said there were plenty of reasons to eat more veg.

The work focused on how vegetables alter the lining of the intestines, by studying mice and miniature bowels growing in the lab.

Like the skin, the surface of the bowels is constantly being regenerated in a process that takes four to five days.

But this constant renewal needs to be tightly controlled, otherwise it could lead to cancer or gut inflammation.

And the work, published in the journal Immunity, showed chemicals in cruciferous vegetables were vital.

From kitchen to cancer prevention?

The researchers investigated a chemical called indole-3-carbinol, which is produced by chewing such vegetables.

“Make sure they’re not overcooked, no soggy broccoli,” said researcher Dr Gitta Stockinger.

The chemical is modified by stomach acid as it continues its journey through the digestive system.

In the lower bowel, it can change the behaviour of stem cells, which regenerate the bowel lining, and of immune cells that control inflammation.

The study showed diets high in indole-3-carbinol protected the mice from cancer, even those whose genes put them at very high risk of the disease.

Without the protective diet, the gut cells divided uncontrollably.

Dr Stockinger added: “Even when the mice started developing tumours and we switched them to the appropriate diet, it halted tumour progression.”

Presentational white space

Signs of bowel cancer include persistent:

  • blood in the stools
  • changes in bowel habits, such as going to the toilet more often
  • tummy pain, bloating or discomfort
Presentational white space

Dr Stockinger said the findings were a “cause for optimism”.

She has reduced the amount of meat she eats and now consumes a lot more vegetables.

She told the BBC: “A lot of dietary advice we’re getting changes periodically – it is very confusing and not clear cut what the causes and consequences are.

“Just telling me it’s good for me without a reason will not make me eat it.

“With this study, we have the molecular mechanisms about how this system works.”

Prof Tim Key, from Cancer Research UK, said: “This study in mice suggests that it’s not just the fibre contained in vegetables like broccoli and cabbage that help reduce the risk of bowel cancer, but also molecules found in these vegetables too.

“Further studies will help find out whether the molecules in these vegetables have the same effect in people, but in the meantime there are already plenty of good reasons to eat more vegetables.”

Follow James on Twitter.

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California School Teacher Out With Cancer Has To Pay The Salary Of Her Substitute

(THIS ARTICLE IS COURTESY OF NBC NEWS)

 

San Francisco parents rally around teacher with cancer who has to pay for her own substitute

Parents at Glen Park Elementary School are pitching in to help the teacher fighting breast cancer cover the costs for her substitute.

 

 

Shanghai China: Focus on cancer prevention

(THIS ARTICLE IS COURTESY OF SHANGHAI CHINA’S ‘SHIELD’ NEWS)

 

Focus on cancer prevention

Cancer morbidity in Shanghai has risen 141 percent in the past four decades, according to the latest data released by local health authorities.

But the rate of deaths among cancer patients dropped by 42 percent in this period due to better screening, registration and monitoring.

This week is the city’s Cancer Prevention and Treatment Week with various events promoting cancer prevention.

An opening ceremony was held on Sunday in Changning District which included a walking race.

Data shows that almost 30 percent of local adults do not engage in physical activities and more than 30 percent are overweight. Nearly 10 percent suffer obesity.

Research shows that 40 percent of the causes of cancer in China are bad habits such as lack of exercise, poor diet, smoking and drinking.

Residents who want to know more about cancer and related activities can find information on the WeChat accounts of the local heath commission and center for disease control and prevention.

By 2015, cancer was the second major cause of death in Shanghai.

More than 70,000 people in Shanghai were diagnosed with cancer and nearly 40,000 died as a result in 2015.

Giving cancer patients hope is as valuable as giving them medicine

(THIS ARTICLE IS COURTESY OF THE TIMES OF ISRAEL)

 

Giving cancer patients hope is as valuable as giving them medicine

Israeli cancer patients rely on ICSN’s volunteers and services to help them cope, fight, and recover

Families grappling with the double pressures of watching their children suffer through cancer while simultaneously having earn a living benefit most from ICSN's services, such as transport and financial assistance.

Families grappling with the double pressures of watching their children suffer through cancer while simultaneously having earn a living benefit most from ICSN’s services, such as transport and financial assistance.

To recover from cancer, having the best doctors, treatment, or medication is not enough. Without hope and personal connection, the prognosis for cancer patients is decidedly poorer. This is exactly why Israel Cancer Support Network (ICSN) offers cancer patients and their families the warmth they need to survive emotionally and the firm support they need to meet the challenges of suffering through painful cancer treatments. 

The emotional, physical, and fiscal strain of treating cancer, from arranging doctors’ appointments to meeting personal expenses and trying to maintain a “normal” family life, are hurdles that many have a tremendously difficult time overcoming.

In less than a decade, ICSN has helped over 11,000 families dealing with cancer, giving 50,000 car rides to cancer patients in need of transportation to the hospital and back. That comes out to 150 trips each day. ICSN uses a network of volunteers to create a community of support throughout Israel. Over 2,000 multilingual volunteers from the Jerusalem metro area and further away take time out of their busy lives to transport cancer-stricken children and adults to and from the hospital, around the clock year-round.

But these services represent only a fraction of what ICSN does.

ICSN sets up fully stocked, 24/7 coffee stations in cancer wards so that patients and families can savor a hot drink at any hour of the day. In its 15-year history, the organization has served over a million cups of coffee to cancer patients. ICSN also assists patients with the herculean task of gaining access to top doctors with long waiting lists for appointments.

The bottom line is that ICSN’s services are integral to the recovery of those who use them.

Many families suffer extreme difficulties as a result of cancer treatment and the financial damage caused by months of treatments can be crippling. Patients often lose their jobs due to the inability to work while parents miss countless hours of work accompanying their children to treatments. ICSN eases the burden by offering cash stipends and gift certificates to cover the cost of household help, including shoes, clothing, basic food items and life-saving drugs.

But beyond the financial, physical, and logistical help they provide, ICSN most importantly furnishes cancer patients with hope.

“A smiling volunteer driver picking you up in the middle of the night with his car to take you to the hospital is just as valuable as the cancer treatment itself,” said Shlomi, a recipient of ICSN’s services.

Personal outreach has a distinct therapeutic effect, according to Professor Dina Ben-Yehuda, director of Hematology at Hadassah Ein-Kerem and professor of Hematology at Hebrew University’s Faculty of Medicine. “When you battle a disease like cancer, the supporters are just as important as the fighters.”

During the High Holidays, ICSN goes the extra mile to give cancer patients in need the serene conditions in which to celebrate and usher in the new year.

ICSN functions entirely through donations with no external support.

Learn more about how you can help cure cancer.

Groundbreaking Treatment Cures Woman’s Advanced Breast Cancer in World First

(THIS ARTICLE IS COURTESY OF THE GUARDIAN)

 

Groundbreaking Treatment Cures Woman’s Advanced Breast Cancer in World First

A Florida woman is still alive thanks to a unique style of immunotherapy in treating her aggressive breast cancer.

Doctors and cancer patients around the world are taking note of an incredible piece of news. A new therapy has reportedly cured a woman diagnosed with advanced breast cancer which had spread throughout her body.

This marks the first time that a woman with advanced, late-stage breast cancer has successfully been treated with immunotherapy. The team of doctors used patient Judy Perkins’s own immune cells to combat the disease.

Perkins was just 49 years old when the engineer discovered she’d been picked for a new therapy. She’d already undergone chemo treatments which continued to fail her. At best, Perkins had three years left to live.

Doctors from the US National Cancer Institute located in Maryland suggested the immunotherapy. They called her response to the treatment “remarkable.”

“My condition deteriorated a lot towards the end, and I had a tumour pressing on a nerve, which meant I spent my time trying not to move at all to avoid pain shooting down my arm. I had given up fighting,” Perkins said in an interview with The Guardian. “After the treatment dissolved most of my tumours, I was able to go for a 40-mile hike.”

Laszlo Radvanyi serves as a scientific director at the Ontario Institute for Cancer Research. Like many keeping up with this news, Radvanyi was not involved in treating Perkins. However, he’s certainly taking notice — calling the treatment “an unprecedented response in such advanced breast cancer.”

“We are now at the cusp of a major revolution in finally realising the elusive goal of being able to target the plethora of mutations in cancer through immunotherapy.”

“We are now at the cusp of a major revolution in finally realising the elusive goal of being able to target the plethora of mutations in cancer through immunotherapy,” Radvanyi said.

Doctors now hope for a major revolution in treatment opportunities available for patients. Some research teams are already developing massive clinical trials to determine just how effective immunotherapy could be for certain patients.

Simon Vincent, director of research at Breast Cancer Now, told interviewers: “This is a remarkable and extremely promising result, but we need to see this effect repeated in other patients before giving hope of a new immunotherapy for incurable metastatic breast cancer.

“Metastatic breast cancer remains incurable, and if we are to finally stop women dying we urgently need to find new ways to target and stop the spread of the disease. We are thrilled by this early finding, but we must remember that this type of immunotherapy remains an experimental approach that has a long way to go before it might be routinely available to patients.”

The process of immunotherapy takes biopsies of the primary tumor and its metastases to determine any mutations specific to a patient’s cancer. Those immune cells that made it through tumor tissue then get cultivated into billions of immune cells in a lab. The tumor tissue itself goes through a bit of gene sequencing so researchers know the main mutations of the tissue. The immune cells being grown then get analyzed to see which ones can target cancer specifically. Those immune cells are the ones that get put back into a patient in order to kill the cancer cells.

SCIENCE

18-Year-Old Boy Designs a Bra That Can Detect Breast Cancer

Perkins had over 80 billion immune cells put into her body. After 42 weeks of treatment, Perkins was declared free of cancer.

She’s been free of cancer ever since.

“It feels miraculous, and I am beyond amazed that I have now been free of cancer for two years,” Perkins said.

“I had resigned my job and was planning on dying. I had a bucket-list of things I needed to do before the end, like going to the Grand Canyon,” she added. “Now, I have gone back to normal everyday life.”

Via: The Guardian

New nano treatment gives cancer patients fresh hope

(THIS ARTICLE IS COURTESY OF SHANGHAI CHINA’S NEWS AGENCY ‘SHINE’)

 

New nano treatment gives cancer patients fresh hope

The world’s first surgery using NanoGun technology — jointly developed by Chinese and French scientists — was performed on a lung cancer patient in Shanghai yesterday.

The new minimally invasive treatment, which can be used on patients deemed no longer healthy enough for chemotherapy, injects the radioactive element rhenium-188 covered with nano-particles, including nitroimidazole — an organic matter.

While engulfing the nitroimidazole, the cancer cells also take in the rhenium, which eventually kills the tumor.

The patient, 71, was in the terminal stage of lung cancer and was too ill for further chemotherapy.

“It usually takes three days for the rhenium to kill the cancer cells,” said Gao Yong, the doctor in charge of the operation at Shanghai East Hospital. “There won’t be any side effects (from the rhenium) as the element will lose its radioactivity after three days.”

NanoGun is a Shanghai-based technology developed from scratch. It won China’s top innovation award in 2016.

Yang Guanghua, one of the scientists who helped develop the technology, said that although rhenium had long been ideal to treat cancer, there had been no ideal medium for delivery. It often diffused throughout the body and was hard to be absorbed by the irregular shaped cancer cells.

It took Yang and his colleges almost 10 years to find the right coating material, nitroimidazole, which matches perfectly with rhenium to make sure it directly reaches the nidus, or “nest”, of the cancer.

“Diffusion of the element (rhenium) hindered the effectiveness of the treatment in the past,” said Dr. Sadeg Nouredine, one of the French scientists working with Yang.

The surgery, approved by the hospital’s ethics committee as part of the treatment’s clinical trial, was free.

“We are working on the next stage of the technology in the lab,” said Yang. “So that it can hit multiple niduses simultaneously.”

If the trial succeeds the treatment will be available by 2020, by which time Shanghai will have built a pharmaceutical factory and hospital in Songjiang District to provide rhenium.

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